listlabs 炭疽致死因子說明書

時(shí)間：2018/12/10閱讀：302

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上海起發(fā)實(shí)驗(yàn)試劑有限公司
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list biological laboratories公司是世界的科研毒素試劑供應(yīng)商,，其毒素包括霍亂病毒，蛇毒,，百日咳毒素等各類毒素,我公司常年低價(jià)供應(yīng),貨期快.有意者請(qǐng). 百日咳毒素長期現(xiàn)貨供應(yīng),，貨號(hào)181及180,。

listlabs 炭疽致死因子說明書

炭疽毒素Anthrax Toxins

炭疽桿菌是炭疽病的病原體。炭疽桿菌產(chǎn)生的主要毒力因子是γ連接的聚-D-谷氨酸膠囊和由三種成分組成的外毒素,，保護(hù)性抗原（PA）,，致死因子（LF）和水腫因子（EF）。這些蛋白質(zhì)不是單*毒的,，而是以二元組合起作用,。PA（細(xì)胞結(jié)合成分）與LF（酶部分之一）的復(fù)合物被稱為“致死毒素”并可導(dǎo)致死亡。PA和酶促EF一起引起皮膚水腫,。分泌后,，PA被膜肽酶切割，使63kDa羧基末端片段寡聚化成七聚體,。切割是暴露EF和LF的結(jié)合位點(diǎn)的必要步驟,。組裝的PA復(fù)合物和相關(guān)的LF或EF通過胞吞作用進(jìn)入細(xì)胞。PA介導(dǎo)LF和EF向細(xì)胞質(zhì)的轉(zhuǎn)移,，其中這些酶識(shí)別并蛋白水解其靶標(biāo),。LF組分是一種鋅依賴性金屬蛋白酶，可裂解絲裂原活化蛋白激酶激酶（MAPKK）,，從而削弱其功能,，從而阻斷MAPK信號(hào)通路。EF是鈣調(diào)蛋白依賴性腺苷酸環(huán)化酶,，其在細(xì)胞中產(chǎn)生過量的環(huán)AMP,，導(dǎo)致水腫。目前的研究集中于開發(fā)有效的疫苗以及篩選LF酶活性的有效抑制劑,。

含有炭疽LF切割位點(diǎn)的FRET肽底物可作為MAPKKide®獲得,，并可用于評(píng)估LF的酶活性。

炭疽毒素

（炭疽致死因子）

致死因子（LF）是炭疽致死毒素的酶促亞基,。當(dāng)使細(xì)胞中毒時(shí),，LF與細(xì)胞表面的PA結(jié)合，并通過由7種PA單體制成的孔移位,。List Labs提供幾種形式的LF,，均在天然炭疽芽孢桿菌中重組制成主辦。已發(fā)現(xiàn)產(chǎn)品＃172（LF-HMA）的原始形式在N-末端攜帶另外兩種氨基酸,，組氨酸和甲硫氨酸,。產(chǎn)品＃169（LF-A）是一種較新的天然形式，在N-末端具有丙氨酸,，類似于天然毒素,。兩種形式的致死因子，LF-A和LF-HMA,。此外,，這兩種類型的LF都是作為質(zhì)量記錄（QD）試劑生產(chǎn)的，其特點(diǎn)是在生產(chǎn)過程中對(duì)組件,，設(shè)備和環(huán)境的更大控制以及對(duì)終產(chǎn)品（產(chǎn)品＃9169和＃9172）的細(xì)胞活動(dòng)的附加質(zhì)量控制測(cè)試,。

后，List Labs產(chǎn)生LF,，LF E687C的突變形式,，在鋅結(jié)合位點(diǎn)具有Glu至Cys取代，消除了酶活性,。

炭疽毒素

（炭疽致死因子）

炭疽致死因子（LF）,，
來自炭疽芽孢桿菌的重組體炭疽致死因子（LF），
來自炭疽芽孢桿菌的重組體炭疽致死因子（LF）,，
來自炭疽芽孢桿菌的重組體窗體底端

炭疽致死因子（LF）,，
來自炭疽芽孢桿菌的重組體

＃172B（1毫克） - 700.00美元

＃172C（10毫克） - 2,325.00美元

＃172L（1毫克） - 700.00美元

炭疽毒素

（炭疽致死因子）

來自炭疽芽孢桿菌的炭疽致死因子（LF），
重組,，突變體E687C

＃176A（0.1毫克） - 280.00美元

＃176B（1毫克） - $ 475.00

炭疽毒素

（炭疽致死因子）

炭疽致死因子（LF-A）,，來自炭疽芽孢桿菌天然序列的重組體

＃169L（液體）（0.2毫克） - 320.00美元

貨號(hào)	品名	規(guī)格	價(jià)格
list104	Cholera Toxin B Subunit (Choleragenoid) in low salt¹	0.5mg	4930
list106	Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC)	0.2mg	9775
list112	Cholera Toxin B Subunit Biotin	0.2mg	9775
list122	Enterotoxin Type B from Staphylococcus aureus^1,3	0.5mg	7225
list123	Enterotoxin Type B Toxoid from Staphylococcus aureus ^1,3	0.25mg	8075
list139	Botulinum Neurotoxin Type B Toxoid	10µg	6800
list150	Diphtheria Toxin, unnicked from Corynebacterium diphtheriae	1mg	11050
list151	Diphtheria Toxoid, from Corynebacterium diphtheriae	0.5mg	10625
list153	Toxin A Toxoid from Clostridium difficile	100µg	11900
list156	Pasteurella Multocida Toxin	50µg	8075
list160	Exotoxin A from Pseudomonas aeruginosa	1mg	4420
list161	Shiga Toxin 1 from Escherichia coli^1,4,8	10µg	11900
list162	Shiga Toxin 2 from Escherichia coli^1,4,8	10µg	11050
list174	Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis	0.5mg	9350
list175	Anthrax PA 63 - Fluorescein Isothiocyanate Conjugate (PAFITC)	50µg	7225
list180	Pertussis Toxin Islet-Activating Protein Lyophilized in buffer	50µg	5525
list181	Pertussis Toxin Islet Activating Protein Lyophilized (Salt-Free)	50µg	5525
list184	Pertussis Toxin Mutant	50µg	5525
list186	FIMBRIAE 2/3 from B. pertussis	50µg	5950
list187	Pertactin from Bordetella pertussus (69 kDa Protein)	50µg	4590
list193	Tetanus Toxin C Fragment	10µg	9350
list201	LPS from Escherichia coli O111:B4	5mg	3230
list206	LPS, Escherichia coli 0157:H7	10.0mg	4760
list225	LPS from Salmonella typhimurium	5mg	2890
list301	LPS from Escherichia coli J5 (Rc)	5mg	2890
list302	LPS from Escherichia coli K12, D31m4 (Re)	5mg	2890
list304	LPS from Salmonella minnesota R595 (Re)	5mg	2890
list314	LPS from Escherichia coli K12 strain LCD25	1mg	2890
list400	HPT™ LPS, highly purified from Bordetella Pertussis 165	1mg	5100
list401	Lipid A monophosphoryl from Salmonella minnesota R595	1mg	3400
list421	Ultra Pure LPS from Escherichia coli O111:B4	1mg	3570
list423	Ultra Pure LPS from Escherichia coli O55:B5	1mg	3570
list433	LISTÔ HPTÔ, LPS, highly purified Escherichia coli O113 LPS	1mg	4080
list434	Ultra Pure LPS from Salmonella minnesota R595 (Re)	1mg	3400
list520	SNAPtide® Peptide Substrate (o-Abz/Dnp) (U.S. Patent #6,504,006)	200nmoles	9775
list521	SNAPtide® Peptide Substrate (FITC/DABCYL) (U.S. Patent #6,504,006)	200nmoles	8500
list523	SNAPtideÒ Peptide Substrate flP6 (DABCYL/5-IAF), U.S. Patent Pending #61/252,675	200nmoles	8500
list525	Control Peptide for SNAPtideÒ #520	200nmoles	8500
list526	Control Peptide for SNAPtide® #521	200nmoles	8500
list528	Unquenched Calibration Peptide for SNAPtide® 521	50nmoles	2890
list529	Unquenched Calibration Peptide for SNAPtide® 520	50nmoles	2890
list530	MAPKKide® Peptide Substrate (o-Abz/Dnp)	200nmoles	5100
list531	MAPKKide® Peptide Substrate (DABCYL/FITC)	200nmoles	5100
list532	MAPKKide® Plus (AMC) Specific Substrate for Anthrax Lethal Factor	100nmoles	4250
list539	Unquenched Calibration Peptide for MAPKKideÒ 530	50nmoles	2890
list540	VAMPtide® Peptide Substrate (o-Abz/Dnp)	200nmoles	8500
list541	VAMPtide® Peptide Substrate (FITC/DABCYL)	200nmoles	8500
list542	VAMPtide® Peptide Substrate (PL 150, Pya/Nop)	200nmoles	8500
list549	Calibration Fluorophore for VAMPtideÒ 540	100nmoles	2890
list550	SNAP Etide® Peptide Substrate (o-Abz/Dnp)	100nmoles	6800
list560	SYNTAXtideÒ Peptide Substrate (o-Abz/Dnp) for C. botulinum Type C	200nmoles	8500
list703	Anti-Cholera Toxin B Subunit (Goat)	0.1ml	3060
list752	Anti-Toxin A from Clostridium difficile (Goat)	0.5ml	3230
list760	Anti-Exotoxin A (Goat)	0.5ml	3400
list781	Anti-Protective Antigen from Bacillus anthracis (Goat) affinity purified, Liquid^6,7	0.1mg	7055
list100B	Cholera Toxin (Azide Free)¹	1mg	3400
list101B	Cholera Toxin¹	1mg	3400
list101C	Cholera Toxin¹	2mg	5355
list116L	Alpha Toxin from C. septicum^4,6,7	50µg	4930
list126A	Epsilon Toxin from C. perfringens^1,4,8	0.1mg	5950
list128A	Botulinum Neurotoxin Type A Complex from Clostridium botulinum^1,3	10µg	2890
list128C	Botulinum Neurotoxin Type A Complex from Clostridium botulinum^1,3	100µg	5440
list130A	Botulinum Neurotoxin Type A from Clostridium botulinum^1,3	10µg	5440
list130B	Botulinum Neurotoxin Type A from Clostridium botulinum^1,3	100µg	13600
list133L	Botulinum Neurotoxin Type A Toxoid, Liquid^6,7	10µg	5440
list136A	Botulinum Neurotoxin Type B. from Clostridium botulinum ^1,3	10µg	5100
list136B	Botulinum Neurotoxin Type B, from Clostridium botulinum^1,3	100µg	17000
list138A	Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum^1,3	10µg	2890
list138B	Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum^1,3	100µg	7225
list140A	Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum^1,3	10µg	2890
list140B	Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum^1,3	100µg	8925
list141A	Botulinum Neurotoxin Type E, Nicked, from Clostridium botulinum^1,3	10µg	8075
list146A	Botulinum Neurotoxin Type D, Nicked, Recombinant from Clostridium botulinum^1,3	10µg	5355
list149A	Diphtheria Toxin CRM Mutant	0.25 mg	8500
list152C	Toxin A from Clostridium difficile	100µg	9010
list154A	Toxin B Toxoid from Clostridium difficile	20µg	2890
list15	Toxin B from Clostridium difficile	2µg	2890
list155B	Toxin B from Clostridium difficile	20µg	8500
list155C	Toxin B from Clostridium difficile	200µg	15300
list155L	Toxin B from Clostridium difficile, Liquid^6,7	50µg	9860
list157A	Binary Toxin from Clostridium difficile, A Subunit	20µg	5950
list158A	Binary Toxin from Clostridium difficile, B Subunit	40µg	5950
list159A	Glutamate Dehydrogenase (GDH) from Clostridium difficile^6,7	0.1mg	4930
list169A	Anthrax Lethal Factor (LF-A) , Recombinant from Bacillus anthracis Native Sequence	0.1mg	3060
list169B	Anthrax Lethal Factor (LF-A),Recombinant from Bacillus anthracis Native Sequence	1mg	12750
list169L	Anthrax Lethal Factor (LF-A),Recomb.from Bacillus anthracis ^5,7	0.2 mg	5950
list171E	Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis	0.5mg	8755
list172B	Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis	1mg	12750
list172C	Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis	10mg	39525
list172L	Lethal Factor, Recomb from Bacillus anthracis, froz liq ^5,7	1.0 mg	12750
list173B	Anthrax Edema Factor (EF), Recombinant Mutant S447N from Bacillus anthracis	0.5mg	16150
list176A	Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis	0.1mg	5100
list176B	Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis	1mg	16150
list177A	Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis	50µg	5950
list177B	Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis	0.25mg	11050
list178A	Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis	0.1mg	2890
list179A	Pertussis Toxin Islet Activating Protein (in glycerol)^6,7	50µg	4845
list188L	Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid^5,7	50µg	5270
list190A	Tetanus Toxin²	25µg	2890
list190B	Tetanus Toxin²	100µg	9350
list191A	Tetanus Toxoid	25µg	4675
list191B	Tetanus Toxoid	100µg	13600
list196A	C-fragment, FITC Conjugate	10µg	6800
list203A	LPS, Escherichia coli O55:B5	2.5 mg	3060
list500A	SNAP-25 Recomb Protein Substrate for C. botulinum Type A and E Neurotoxin	100µg	5525
list510A	GST Synaptobrevin-2 Protein Recomb. Protein Substrate for C. botulinum Type B,D and F	100µg	5950
list610A	Botulinum Neurotoxin Type A Light Chain, Recombinant¹	10µg	4760
list611A	Botulinum Neurotoxin Type A Light Chain, GST Fusion, Recombinant¹	15µg	4760
list612A	Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain¹	50µg	4760
list613A	Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain, GST Fusion¹	50µg	4760
list620A	Botulinum Neurotoxin Type B Light Chain, Recombinant¹	10µg	8500
list622A	Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain¹	50µg	4760
list623A	Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain, GST Fusion¹	50µg	4760
list62	Botulinum Neurotoxin Type C Light Chain, Recombinant¹	10µg	8500
list630A	Botulinum Neurotoxin Type D Light Chain, Recombinant¹	10µg	5695
list650A	Tetanus Toxin Light Chain, Recombinant	10µg	3825
list690B	Receptor for C. botulinum Type A Neurotoxin GST-SV2c luminal domain (U.S. Patent #8,476,024)	100nmoles	6800
list730A	Anti-Botulinum Neurotoxin, Type A (Chicken lgY), Liquid^6,7	0.1mg	5610
list731L	Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Liquid6,7	0.1mg	5950
list736A	Anti-Botulinum Type B (Chicken lgY), Liquid^6,7	0.1mg	5950
list753A	Anti-Clostridium difficile Toxin A (Chicken lgY), Liquid^6,7	0.1mg	5780
list754A	Anti-Clostridium difficile Toxin B (Chicken lgY), Liquid^6,7	0.1mg	5780
list756A	Anti-Clostridium difficile Glutamate Dehydrogenase, lgY, Liquid^6,7	0.1mg	5780
list757A	Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY), Liquid^6,7	0.1mg	5780
list758A	Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid^6,7	0.1mg	5780
list759A	Biotinylated Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid^6,7	0.1mg	5780
list761L	Anti-Shiga Toxin 1 (Rabbit), lgG, Liquid^6,7	0.5mg	3400
list765L	Anti-Shiga Toxin 2 (Rabbit), IgG, Liquid^6,7	0.5mg	2890
list766L	Anti-Shiga Toxin, Camelid Antibody, VHH, Liquid^6,7	0.5mg/ml	5950
list768L	Biotinylated Anti-Lethal Factor from B. anthracis, IgY, Liquid^6,7	0.1mg	5950
list769B	Anti-Lethal Factor from Bacillus anthracis (Chicken lgY), Liquid^6,7	0.2mg	8500
list771B	Anti-Protective Antigen from Bacillus anthracis (Goat)	1mg	2890
list772B	Anti-Lethal Factor from Bacillus anthracis (Goat)	1.0 mg	2890
list773L	Anti-Edema Factor from Bacillus anthracis (Goat), Liquid^6,7	1mg	2890

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上海起發(fā)實(shí)驗(yàn)試劑有限公司

listlabs 炭疽致死因子說明書

炭疽毒素Anthrax Toxins

炭疽毒素

（炭疽致死因子）

炭疽毒素

（炭疽致死因子）

炭疽毒素

（炭疽致死因子）

炭疽毒素

（炭疽致死因子）

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