list biological 758A

時(shí)間：2018-12-10閱讀：1167

list biological laboratories公司是世界的科研毒素試劑供應(yīng)商,，其毒素包括霍亂病毒,，蛇毒，百日咳毒素等各類毒素,我公司常年低價(jià)供應(yīng),貨期快.有意者請(qǐng). 百日咳毒素長(zhǎng)期現(xiàn)貨供應(yīng),，貨號(hào)181及180,。

list biological 758A

艱難毒素Difficile Toxins

一種主要的醫(yī)院病原體,，艱難梭菌（Clostridium difficile）引起抗生素相關(guān)性結(jié)腸炎和腸道炎癥性疾病，一起稱為CDI,。

C艱難梭菌毒素如何引起腹瀉,？ 通過(guò)釋放兩種大蛋白腸毒素，艱難梭菌毒素A（TcdA）和艱難梭菌毒素B（TcdB）,，艱難梭菌介導(dǎo)炎性腹瀉并損害腸??上皮細(xì)胞,。施用于培養(yǎng)細(xì)胞時(shí)的毒素都會(huì)破壞細(xì)胞骨架并引發(fā)細(xì)胞凋亡依賴性細(xì)胞凋亡，盡管艱難梭菌毒素B的效力比艱難梭菌多很多倍,。毒素A.兩種毒素還激活腸上皮細(xì)胞和免疫細(xì)胞以產(chǎn)生細(xì)胞因子和趨化因子,，可能導(dǎo)致與嚴(yán)重CDI相關(guān)的并發(fā)癥。TcdA和TcdB的細(xì)胞內(nèi)靶標(biāo)是RhoGTP酶,，其調(diào)節(jié)許多宿主細(xì)胞過(guò)程,，包括建立上皮屏障和免疫細(xì)胞的遷移和信號(hào)傳導(dǎo)。當(dāng)Rho蛋白被艱難梭菌毒素A或B 糖基化時(shí),，信號(hào)被破壞,，導(dǎo)致CDI的腸損傷和炎癥特征。

List Labs C. Difficile Toxins參與了診斷的研究和開發(fā),。

抗艱難梭菌二元毒素B亞基（雞lgY）

產(chǎn)品＃和尺寸

＃758A（0.1毫克） - 320.00美元

艱難梭菌是引起抗生素相關(guān)性腹瀉和假膜性大腸桿菌的病原體,。

1，2它產(chǎn)生兩種主要的外毒素(毒素A和毒素B),。

大型梭狀細(xì)胞毒素科,。一些艱難梭菌還產(chǎn)生一種二價(jià)ADP-核糖化毒素(CDT)，這種毒素可以修飾actin3 CDT二元毒素在疾病誘導(dǎo)中的致病作用艱難梭菌的ED尚不清楚,，但從結(jié)腸炎患者中分離出的約10%的菌株含有CDT二元毒素基因,。

4,，5艱難梭菌A和B為高分子量葡糖基轉(zhuǎn)運(yùn)體。抑制GTPases Rho家族成員的rase,。毒素A被稱為腸毒素,，分子量為300 kDa，等電點(diǎn)為5.3,。毒素B,，被稱為細(xì)胞毒素，分子量為270 kDa,，pl為4.1,。毒素A和毒素B通過(guò)蘇氨酸殘基的葡萄糖化使Rho,、RAC和Cdc 42等小GTPase失活,。6，7,，8抑制這些GTPase S導(dǎo)致信號(hào)轉(zhuǎn)導(dǎo)級(jí)聯(lián)的關(guān)閉,，導(dǎo)致細(xì)胞骨架的解聚，某些應(yīng)激激活蛋白激酶的基因轉(zhuǎn)錄,，磷脂合成的下降,。

Ylinositol 4，5二磷酸甚至可能導(dǎo)致細(xì)胞極化的喪失9細(xì)胞骨架結(jié)構(gòu)的喪失導(dǎo)致細(xì)胞的四舍五入,，這種結(jié)構(gòu)的喪失可能是宿主對(duì)C的反應(yīng)的原因,。艱難。毒素A和B所針對(duì)的GTP酶與許多細(xì)胞反應(yīng)有關(guān),，但這些毒素具有不同的生理效應(yīng),。這兩種毒素都會(huì)刺激皮膚，增加維生素A,。 [10]只有毒素A在上皮細(xì)胞表面有一個(gè)結(jié)合位點(diǎn),，即碳水化合物11，這可能與兔回腸的劇烈反應(yīng)有關(guān),。23,，

13毒素B是一種p型毒素。組織培養(yǎng)中哺乳動(dòng)物細(xì)胞的細(xì)胞毒素14,，

15毒素B在細(xì)胞四舍五入中的毒性至少是毒素A的1000倍,。通過(guò)抑制信號(hào)轉(zhuǎn)導(dǎo)級(jí)聯(lián)，毒素A 毒素B可以阻斷下游的反應(yīng),。毒素A可誘導(dǎo)白介素8.

16毒素B可能阻斷5-羥色胺的釋放,，

17以及刺激磷脂的產(chǎn)生 ESC和D.

18，19由于具有影響細(xì)胞骨架解聚的能力,，毒素B被證明能抑制雙相肌肉收縮,。

20艱難梭菌毒素A和B有63%的同源性,。每種毒素的C-末端第三位都是由被稱為梭狀重復(fù)寡肽(作物)的高度序列組成。 Y抗原,。其余的N端三分之二的毒素A和B在序列同源性方面不太相似,，但每種蛋白質(zhì)的這一部分都含有葡萄糖。

22,，23 CDT二元毒素是ADP-核糖轉(zhuǎn)移酶家族(ADPRT)的成員,。3 CDT二元毒素與C.肉毒桿菌C2毒素同屬于AB二元毒素亞家族。產(chǎn)氣莢膜的毒素,。

24該二元毒素由兩個(gè)獨(dú)立產(chǎn)生的組分組成,，即酶組分A亞基CdtA(48 KD)和結(jié)合和易位復(fù)合物。 Nent B亞基CdtB(94 KD)介導(dǎo)CdtA細(xì)胞的進(jìn)入,。

25 cdt二元毒素引起肌動(dòng)蛋白細(xì)胞骨架的解聚和微管基膜突起的形成,。

[26]CDT二價(jià)毒素B亞基cdtB是cdtA進(jìn)入TH的必需物質(zhì)。26 CDT二進(jìn)毒素cdtB亞基cdtB參與了高致病性艱難梭菌的粘附和定植,。

27 CdtB組分必須通過(guò)切割激活,，然后在細(xì)胞表面形成七肽，并與特定的細(xì)胞表面受體結(jié)合,。細(xì)胞表面受體已被識(shí)別 28隨后,，CdtA與CdtB結(jié)合，通過(guò)受體介導(dǎo)的內(nèi)吞作用進(jìn)入細(xì)胞,。cdtA的N端與INTERA有關(guān),。在cdtB作用下，C端含有酶活性,。29根據(jù)lota毒素的活性,，預(yù)測(cè)cdp-核糖單聚體G-actin在arg 17上將不可逆轉(zhuǎn)。 7殘留,。這種ADP-核糖基化將阻止G-肌動(dòng)蛋白與F-肌動(dòng)蛋白的聚合,，破壞F-actin：G-actin的平衡，從而導(dǎo)致細(xì)胞的四舍五入和細(xì)胞死亡,。

產(chǎn)品僅用于研究目的,，不用于人類或診斷劑。

貨號(hào)	品名	規(guī)格	價(jià)格
list104	Cholera Toxin B Subunit (Choleragenoid) in low salt¹	0.5mg	4930
list106	Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC)	0.2mg	9775
list112	Cholera Toxin B Subunit Biotin	0.2mg	9775
list122	Enterotoxin Type B from Staphylococcus aureus^1,3	0.5mg	7225
list123	Enterotoxin Type B Toxoid from Staphylococcus aureus ^1,3	0.25mg	8075
list139	Botulinum Neurotoxin Type B Toxoid	10µg	6800
list150	Diphtheria Toxin, unnicked from Corynebacterium diphtheriae	1mg	11050
list151	Diphtheria Toxoid, from Corynebacterium diphtheriae	0.5mg	10625
list153	Toxin A Toxoid from Clostridium difficile	100µg	11900
list156	Pasteurella Multocida Toxin	50µg	8075
list160	Exotoxin A from Pseudomonas aeruginosa	1mg	4420
list161	Shiga Toxin 1 from Escherichia coli^1,4,8	10µg	11900
list162	Shiga Toxin 2 from Escherichia coli^1,4,8	10µg	11050
list174	Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis	0.5mg	9350
list175	Anthrax PA 63 - Fluorescein Isothiocyanate Conjugate (PAFITC)	50µg	7225
list180	Pertussis Toxin Islet-Activating Protein Lyophilized in buffer	50µg	5525
list181	Pertussis Toxin Islet Activating Protein Lyophilized (Salt-Free)	50µg	5525
list184	Pertussis Toxin Mutant	50µg	5525
list186	FIMBRIAE 2/3 from B. pertussis	50µg	5950
list187	Pertactin from Bordetella pertussus (69 kDa Protein)	50µg	4590
list193	Tetanus Toxin C Fragment	10µg	9350
list201	LPS from Escherichia coli O111:B4	5mg	3230
list206	LPS, Escherichia coli 0157:H7	10.0mg	4760
list225	LPS from Salmonella typhimurium	5mg	2890
list301	LPS from Escherichia coli J5 (Rc)	5mg	2890
list302	LPS from Escherichia coli K12, D31m4 (Re)	5mg	2890
list304	LPS from Salmonella minnesota R595 (Re)	5mg	2890
list314	LPS from Escherichia coli K12 strain LCD25	1mg	2890
list400	HPT™ LPS, highly purified from Bordetella Pertussis 165	1mg	5100
list401	Lipid A monophosphoryl from Salmonella minnesota R595	1mg	3400
list421	Ultra Pure LPS from Escherichia coli O111:B4	1mg	3570
list423	Ultra Pure LPS from Escherichia coli O55:B5	1mg	3570
list433	LISTÔ HPTÔ, LPS, highly purified Escherichia coli O113 LPS	1mg	4080
list434	Ultra Pure LPS from Salmonella minnesota R595 (Re)	1mg	3400
list520	SNAPtide® Peptide Substrate (o-Abz/Dnp) (U.S. Patent #6,504,006)	200nmoles	9775
list521	SNAPtide® Peptide Substrate (FITC/DABCYL) (U.S. Patent #6,504,006)	200nmoles	8500
list523	SNAPtideÒ Peptide Substrate flP6 (DABCYL/5-IAF), U.S. Patent Pending #61/252,675	200nmoles	8500
list525	Control Peptide for SNAPtideÒ #520	200nmoles	8500
list526	Control Peptide for SNAPtide® #521	200nmoles	8500
list528	Unquenched Calibration Peptide for SNAPtide® 521	50nmoles	2890
list529	Unquenched Calibration Peptide for SNAPtide® 520	50nmoles	2890
list530	MAPKKide® Peptide Substrate (o-Abz/Dnp)	200nmoles	5100
list531	MAPKKide® Peptide Substrate (DABCYL/FITC)	200nmoles	5100
list532	MAPKKide® Plus (AMC) Specific Substrate for Anthrax Lethal Factor	100nmoles	4250
list539	Unquenched Calibration Peptide for MAPKKideÒ 530	50nmoles	2890
list540	VAMPtide® Peptide Substrate (o-Abz/Dnp)	200nmoles	8500
list541	VAMPtide® Peptide Substrate (FITC/DABCYL)	200nmoles	8500
list542	VAMPtide® Peptide Substrate (PL 150, Pya/Nop)	200nmoles	8500
list549	Calibration Fluorophore for VAMPtideÒ 540	100nmoles	2890
list550	SNAP Etide® Peptide Substrate (o-Abz/Dnp)	100nmoles	6800
list560	SYNTAXtideÒ Peptide Substrate (o-Abz/Dnp) for C. botulinum Type C	200nmoles	8500
list703	Anti-Cholera Toxin B Subunit (Goat)	0.1ml	3060
list752	Anti-Toxin A from Clostridium difficile (Goat)	0.5ml	3230
list760	Anti-Exotoxin A (Goat)	0.5ml	3400
list781	Anti-Protective Antigen from Bacillus anthracis (Goat) affinity purified, Liquid^6,7	0.1mg	7055
list100B	Cholera Toxin (Azide Free)¹	1mg	3400
list101B	Cholera Toxin¹	1mg	3400
list101C	Cholera Toxin¹	2mg	5355
list116L	Alpha Toxin from C. septicum^4,6,7	50µg	4930
list126A	Epsilon Toxin from C. perfringens^1,4,8	0.1mg	5950
list128A	Botulinum Neurotoxin Type A Complex from Clostridium botulinum^1,3	10µg	2890
list128C	Botulinum Neurotoxin Type A Complex from Clostridium botulinum^1,3	100µg	5440
list130A	Botulinum Neurotoxin Type A from Clostridium botulinum^1,3	10µg	5440
list130B	Botulinum Neurotoxin Type A from Clostridium botulinum^1,3	100µg	13600
list133L	Botulinum Neurotoxin Type A Toxoid, Liquid^6,7	10µg	5440
list136A	Botulinum Neurotoxin Type B. from Clostridium botulinum ^1,3	10µg	5100
list136B	Botulinum Neurotoxin Type B, from Clostridium botulinum^1,3	100µg	17000
list138A	Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum^1,3	10µg	2890
list138B	Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum^1,3	100µg	7225
list140A	Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum^1,3	10µg	2890
list140B	Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum^1,3	100µg	8925
list141A	Botulinum Neurotoxin Type E, Nicked, from Clostridium botulinum^1,3	10µg	8075
list146A	Botulinum Neurotoxin Type D, Nicked, Recombinant from Clostridium botulinum^1,3	10µg	5355
list149A	Diphtheria Toxin CRM Mutant	0.25 mg	8500
list152C	Toxin A from Clostridium difficile	100µg	9010
list154A	Toxin B Toxoid from Clostridium difficile	20µg	2890
list15	Toxin B from Clostridium difficile	2µg	2890
list155B	Toxin B from Clostridium difficile	20µg	8500
list155C	Toxin B from Clostridium difficile	200µg	15300
list155L	Toxin B from Clostridium difficile, Liquid^6,7	50µg	9860
list157A	Binary Toxin from Clostridium difficile, A Subunit	20µg	5950
list158A	Binary Toxin from Clostridium difficile, B Subunit	40µg	5950
list159A	Glutamate Dehydrogenase (GDH) from Clostridium difficile^6,7	0.1mg	4930
list169A	Anthrax Lethal Factor (LF-A) , Recombinant from Bacillus anthracis Native Sequence	0.1mg	3060
list169B	Anthrax Lethal Factor (LF-A),Recombinant from Bacillus anthracis Native Sequence	1mg	12750
list169L	Anthrax Lethal Factor (LF-A),Recomb.from Bacillus anthracis ^5,7	0.2 mg	5950
list171E	Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis	0.5mg	8755
list172B	Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis	1mg	12750
list172C	Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis	10mg	39525
list172L	Lethal Factor, Recomb from Bacillus anthracis, froz liq ^5,7	1.0 mg	12750
list173B	Anthrax Edema Factor (EF), Recombinant Mutant S447N from Bacillus anthracis	0.5mg	16150
list176A	Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis	0.1mg	5100
list176B	Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis	1mg	16150
list177A	Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis	50µg	5950
list177B	Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis	0.25mg	11050
list178A	Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis	0.1mg	2890
list179A	Pertussis Toxin Islet Activating Protein (in glycerol)^6,7	50µg	4845
list188L	Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid^5,7	50µg	5270
list190A	Tetanus Toxin²	25µg	2890
list190B	Tetanus Toxin²	100µg	9350
list191A	Tetanus Toxoid	25µg	4675
list191B	Tetanus Toxoid	100µg	13600
list196A	C-fragment, FITC Conjugate	10µg	6800
list203A	LPS, Escherichia coli O55:B5	2.5 mg	3060
list500A	SNAP-25 Recomb Protein Substrate for C. botulinum Type A and E Neurotoxin	100µg	5525
list510A	GST Synaptobrevin-2 Protein Recomb. Protein Substrate for C. botulinum Type B,D and F	100µg	5950
list610A	Botulinum Neurotoxin Type A Light Chain, Recombinant¹	10µg	4760
list611A	Botulinum Neurotoxin Type A Light Chain, GST Fusion, Recombinant¹	15µg	4760
list612A	Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain¹	50µg	4760
list613A	Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain, GST Fusion¹	50µg	4760
list620A	Botulinum Neurotoxin Type B Light Chain, Recombinant¹	10µg	8500
list622A	Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain¹	50µg	4760
list623A	Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain, GST Fusion¹	50µg	4760
list62	Botulinum Neurotoxin Type C Light Chain, Recombinant¹	10µg	8500
list630A	Botulinum Neurotoxin Type D Light Chain, Recombinant¹	10µg	5695
list650A	Tetanus Toxin Light Chain, Recombinant	10µg	3825
list690B	Receptor for C. botulinum Type A Neurotoxin GST-SV2c luminal domain (U.S. Patent #8,476,024)	100nmoles	6800
list730A	Anti-Botulinum Neurotoxin, Type A (Chicken lgY), Liquid^6,7	0.1mg	5610
list731L	Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Liquid6,7	0.1mg	5950
list736A	Anti-Botulinum Type B (Chicken lgY), Liquid^6,7	0.1mg	5950
list753A	Anti-Clostridium difficile Toxin A (Chicken lgY), Liquid^6,7	0.1mg	5780
list754A	Anti-Clostridium difficile Toxin B (Chicken lgY), Liquid^6,7	0.1mg	5780
list756A	Anti-Clostridium difficile Glutamate Dehydrogenase, lgY, Liquid^6,7	0.1mg	5780
list757A	Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY), Liquid^6,7	0.1mg	5780
list758A	Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid^6,7	0.1mg	5780
list759A	Biotinylated Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid^6,7	0.1mg	5780
list761L	Anti-Shiga Toxin 1 (Rabbit), lgG, Liquid^6,7	0.5mg	3400
list765L	Anti-Shiga Toxin 2 (Rabbit), IgG, Liquid^6,7	0.5mg	2890
list766L	Anti-Shiga Toxin, Camelid Antibody, VHH, Liquid^6,7	0.5mg/ml	5950
list768L	Biotinylated Anti-Lethal Factor from B. anthracis, IgY, Liquid^6,7	0.1mg	5950
list769B	Anti-Lethal Factor from Bacillus anthracis (Chicken lgY), Liquid^6,7	0.2mg	8500
list771B	Anti-Protective Antigen from Bacillus anthracis (Goat)	1mg	2890
list772B	Anti-Lethal Factor from Bacillus anthracis (Goat)	1.0 mg	2890
list773L	Anti-Edema Factor from Bacillus anthracis (Goat), Liquid^6,7	1mg	2890

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6：我們還是Santa,Advanced Biotechnologies Inc,Athens Research & Technology,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, Genebridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,omicronbio, Polysciences,prospecbi, QA-BIO,quickzyme,RESEARCH DIETS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc,；worthington-biochem,zyagen等幾十家國(guó)外公司授權(quán)代理,。

7：我們還是invitrogen,qiagen,MiraiBioam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知*批發(fā)，歡迎合作,。

上海起發(fā)實(shí)驗(yàn)試劑有限公司

上海起發(fā)實(shí)驗(yàn)試劑有限公司

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艱難毒素Difficile Toxins

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