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【公司名稱(chēng)】 廣州健侖生物科技有限公司
【市場(chǎng)部】    楊永漢

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*步是要證實(shí)在感染MCMV的小鼠中,，NK細(xì)胞的確產(chǎn)生IL-10。研究人員注意到,，在高度感染的小鼠中,，NK細(xì)胞在被感染約3.5天后產(chǎn)生IL-10，3.5天過(guò)后,，他們會(huì)產(chǎn)生IFN-γ,，這種蛋白質(zhì)有助于增強(qiáng)免疫應(yīng)答，而不是化解,。
在實(shí)驗(yàn)室培養(yǎng)中,，他們發(fā)現(xiàn)，只有那些約3.5天后感染的細(xì)胞會(huì)產(chǎn)生IL-10,。隨后的實(shí)驗(yàn)表明,，本質(zhì)上，暴露于病毒是沒(méi)有必要的,，而是幾輪復(fù)制和增殖(約3天)能夠產(chǎn)生IL-10,。
“總而言之，這些研究表明,，無(wú)論是在體外條件下獨(dú)立的感染下,，還是在體內(nèi)感染過(guò)程中，N??K??細(xì)胞的廣泛增殖與IL-10產(chǎn)生有關(guān),，”作者說(shuō),。
已經(jīng)表明，IL-10的產(chǎn)生是與NK細(xì)胞的增殖有關(guān),，Tarrio,，比隆和同事尋求更多的證據(jù)：觸發(fā)開(kāi)關(guān)產(chǎn)生IL-10的NK細(xì)胞的機(jī)制。
他們?cè)诟腥镜男∈笾?，?duì)NK細(xì)胞增殖前和后的全基因組的構(gòu)象進(jìn)行比較,。他們發(fā)現(xiàn)，NK細(xì)胞尚未發(fā)生增殖過(guò)程時(shí),，IL-10基因被緊緊地包裹起來(lái),，而無(wú)法進(jìn)行表達(dá)。細(xì)胞進(jìn)行增殖時(shí)的IL-10基因被打開(kāi)使其更容易表達(dá),。
“當(dāng)我們得到這些結(jié)果時(shí),，大家都非常興奮，因?yàn)樵隗w內(nèi)的感染過(guò)程中，從一個(gè)細(xì)胞群中挖掘表觀遺傳改變是相當(dāng)不俗的,，” Tarrio說(shuō),。

The first step was to confirm that NK cells did produce IL-10 in mice infected with MCMV. The researchers noted that NK cells produce IL-10 after about 3.5 days of infection in highly infected mice, and after 3.5 days, they produce IFN-γ, a protein that helps boost the immune response rather than defuse .
In laboratory culture, they found that only those cells infected about 3.5 days later produced IL-10. Subsequent experiments showed that, essentially, exposure to the virus is not necessary, but several rounds of replication and proliferation (about 3 days) are capable of producing IL-10.
"All in all, these studies show that the extensive proliferation of N? K cells is associated with IL-10 production both independently of in vitro conditions and during in vivo infection," the authors said.
It has been shown that the production of IL-10 is related to the proliferation of NK cells, and Tarrio Billund and colleagues seek more evidence of the mechanism that triggers the switch to produce IL-10-producing NK cells.
They compared the genome-wide conformation of NK cells before and after their proliferation in infected mice. They found that when NK cells have not yet proliferated, the IL-10 gene is tightly packed and can not be expressed. When the cells proliferate, the IL-10 gene is opened to make it easier to express.
"When we got these results, everyone was very excited, because in the body of the infection, mining epigenetic changes from a cell population is quite impressive," Tarrio said.