戴安提供四種聚合物基質(zhì)的的離子交換色譜柱用于蛋白質(zhì)的分離,，每一種色譜柱都可以提供高效的分辨率以分離蛋白質(zhì)的 異形體,?？梢詫ο嗖钜粋€(gè)氨基酸碎片的蛋白質(zhì)進(jìn)行分離,。 Strong and weak cation-exchange columns for the high-resolution separation of proteins and MAbs
ProPac SCX-10 and WCX-10 strong and weak cation-exchange columns are based on a nonporous core particle that results in high-efficiency separations of protein variants. A hydrophilic layer prevents unwanted secondary interactions. A grafted cation-exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity. • Characterization and quality control assessment of monoclonal antibodies and other proteins • Unequalled resolution • High-efficiency separations with excellent sample recovery • Unmatched column-to-column and lot-to-lot reproducibility • Useful for characterization of related protein variants （e.g.,deamidation and MAb lysine truncation variants） • Highly-efficient peaks with excellent sample recovery • Available in different dimensions and formats for flexibility in method development The ProPac SCX-10 is a strong cation exchange column with sulfonate functional groups. The ProPac WCX-10 has a carboxylate functional group. Both are based on 10 μm nonporous,polymeric beads and coated with a proprietary hydrophilic layer. All ProPac columns are manufactured and tested under the strictest specifications, resulting in unmatched column-to column and lot-to-lot reproducibility. Dionex also offers ProPac columns as a lot select package: either three columns from one lot or three columns from three different lots, to assist quality control scientists in method validation.
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