生物通主辦的“2021生命科學(xué)十·大創(chuàng)新產(chǎn)品”于2022年1月正式揭曉,，Quantum Design中國·新引進(jìn)的NanoView R200全自動(dòng)外泌體熒光檢測分析系統(tǒng),，憑借其*的設(shè)計(jì)理念及·越的性能，榮獲“2021生命科學(xué)十·大創(chuàng)新產(chǎn)品”,！

“生命科學(xué)十·大創(chuàng)新產(chǎn)品”是生物通歷經(jīng)10余年打造的生命科學(xué)科學(xué)儀器行業(yè)·進(jìn),、創(chuàng)新的獎(jiǎng)項(xiàng)之。至今已舉辦十四屆,。本次評(píng)選共有28臺(tái)儀器參選,，經(jīng)過評(píng)審家嚴(yán)格篩選以及廣大科研用戶的投票評(píng)比，終評(píng)選出10·大創(chuàng)新產(chǎn)品,。該獎(jiǎng)項(xiàng)致力于讓大家了解生命科學(xué)發(fā)展的新方向,，也希望新穎的產(chǎn)品能激發(fā)研究者的靈感，推動(dòng)科研進(jìn)程,，助力科研學(xué)者早日攀上科學(xué)研究的高峰,！

全自動(dòng)外泌體熒光檢測分析系統(tǒng)ExoView是美國NanoView Biosciences于2018年研究推出的，該系統(tǒng)經(jīng)推出,，便引起了外泌體域科研工作者的廣泛關(guān)注,。僅兩年已有100多個(gè)實(shí)驗(yàn)室采用該技術(shù),，發(fā)表文獻(xiàn)近百篇，刊載在Cell, Cell Biology, Journal of Extracellular Vesicles等期刊,。ExoView的精準(zhǔn)表征,，為科學(xué)家提供了種無須純化即可直接對(duì)血漿、血清,、尿液,、培養(yǎng)基中的外泌體進(jìn)行表征分析的新方法。能夠提供單個(gè)外泌體水平下的全·方位外泌體表征信息（包括粒徑大小,、分布,、計(jì)數(shù)、攜帶蛋白表達(dá)與生物標(biāo)志物（CD9,，CD81,，CD63等）共定位等），以及多層次和全方面的外泌體測量解決方案,。能夠幫助科學(xué)家更深入地了解外泌體與疾病之間的關(guān)系,，助力疾病診斷和新藥開發(fā)。

ExoView® R200全自動(dòng)外泌體熒光檢測分析系統(tǒng)勢包括：

• 異性捕獲：芯片上可包被多達(dá)6 種捕獲抗體,，異性捕獲含定蛋白標(biāo)記物的外泌體,。

• 對(duì)陽性外泌體計(jì)數(shù)：芯片捕獲外泌體后，可通過單粒子干涉反射成像傳感器（SP-IRIS）技術(shù)直接檢測樣品中外泌體的數(shù)量,。

• 單個(gè)外泌體蛋白共定位分析：檢測每個(gè)外泌體的熒光信號(hào)并進(jìn)行統(tǒng)計(jì),，可獲得熒光共定位信息，用于分析樣品中不同表型外泌體的比例,。

• 無需純化：使用抗體捕獲模式，防止樣品中雜質(zhì)影響結(jié)果,，可直接檢測血液,、尿液和細(xì)胞培養(yǎng)液中的外泌體，未純化樣品的測量結(jié)果與純化后基本致,。

• 粒徑分辨率高：高精度SP-IRIS技術(shù),，可檢測≥50 nm的外泌體，測量結(jié)果與電子顯微鏡檢測結(jié)果基本致,，并統(tǒng)計(jì)生成外泌體的粒徑分布結(jié)果,。

• 可檢測外泌體內(nèi)容物：試劑盒配套相應(yīng)的穿膜劑，可穿透外泌體并對(duì)外泌體內(nèi)容物進(jìn)行染色并檢測,，如下圖所示,，Non-permeabilized時(shí)只能檢測到跨膜蛋白CD9的熒光信號(hào)， Permeabilized后即可檢測到外泌體內(nèi)容物（如PD-L1,、P-tau等）的表達(dá),。

部分應(yīng)用單位：

部分發(fā)表文獻(xiàn)：

• Andras Saftics.(2021) Data evaluation for surface-sensitive label-free methods to obtain real-time kinetic and structural information of thin films: A practical review with related software packages. Advances in Colloid and Interface Science.

• Kyoung-Won Ko.(2021) Integrated Bioactive Scaffold with Polydeoxyribonucleotide and Stem-Cell-Derived Extracellular Vesicles for Kidney Regeneration. ACS Nano.

• Tanina Arab. (2021) Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms. Journal of Extracellular Vesicles.

• Niaz Z.Khan.(2021) Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential. Brain, Behavior, and Immunity.

• Dario Brambilla. (2021) EV Separation: Release of Intact Extracellular Vesicles Immunocaptured on Magnetic Particles. Analytical Chemistry.

• Enkhtuya Radna. (2021) Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth. Lab on a Chip.

• Li, M., Soder. (2021) WJMSC‐derived small extracellular vesicle enhance T cell suppression through PD‐L1. Journal of Extracellular Vesicles.

• Crescitelli, R. (2021) Isolation and characterization of extracellular vesicle subpopulations from tissues. Nature protocols.

• Berger, A. (2021). Local administration of stem cell-derived extracellular vesicles in a thermoresponsive hydrogel promotes a pro-healing effect in a rat model of colo-cutaneous post-surgical fistula. Nanoscale.

• Vidal, M. (2020) Exosomes and GPI-anchored proteins: Judicious pairs for investigating biomarkers from body fluids. Advanced drug delivery reviews.

• K Cho, H Kook.(2020)Study of immune-tolerized cell lines and extracellular vesicles inductive environment promoting continuous expression and secretion of HLA-G from semiallograft immune tolerance during pregnancy. Journal of Extracellular Vesicles.

• Maximillian A. Rogers.(2020)Annexin A1–dependent tethering promotes extracellular vesicle aggregation revealed with single–extracellular vesicle analysis. Cell Biology.

• Annette M. Marleau.(2020)Targeting tumor-derived exosomes using a lectin affinity hemofiltration device. Cancer Research.

• Alessandro Gori.(2020)Membrane-Binding Peptides for Extracellular Vesicles On-Chip Analysis. Journal of Extracellular Vesicles.

• Rossella Crescitelli.(2020)Subpopulations of extracellular vesicles from human metastatic melanoma tissue identified by quantitative proteomics after optimized isolation. Journal of Extracellular Vesicles.

• Maria S. Panagopoulou.(2020) Phenotypic analysis of extracellular vesicles:  a review on the applications of fluorescence. Journal of Extracellular Vesicles.

• WeiYan.(2020) Immune Cell-Derived Exosomes in the Cancer-Immunity Cycle. Trends in Cancer.

• Daniel Bachurski. (2019) Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation. Cell.

為了更好的服務(wù)中國客戶,，Quantum Design中國子公司在北京建立了業(yè)的客戶服務(wù)中心，正式推出業(yè)的全·方位外泌體表征測試服務(wù),，您只需要少量樣品即可獲得全·方位的外泌體表征數(shù)據(jù),。

歡迎各位老師垂詢：010-85120280。前·10名訂購服務(wù)的老師,，可享受8折惠,！

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