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BARD1 rabbit pAb

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      目前已上市了600多種蛋白提取試劑盒（動物、植物、細菌,、昆蟲,、酵母等樣本及細胞器提取）及上千種的細胞檢測的相關(guān)產(chǎn)品-細胞凋亡,、增殖毒性,、細胞周期、膜電位檢測,、細胞器熒光探針,、活性氧ROS檢測、細胞自噬,、細胞耗氧OCR,、細胞外酸化率ECAR、缺氧檢測,、粘附檢測,、鈣離子檢測、膜通透性轉(zhuǎn)換孔檢測,、膜流動性檢測,、外泌體、囊泡提取等,。

 

蛋白提取,，細胞分析

  • Source

    Rabbit

  • Applications

    WB,IHC,ELISA

  • Reactivity

    Human

  • Dilution

    WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:5000. Not yet tested in other applications.

  • Storage

    -20°C/1 year

  • Specificity

    BARD1 Polyclonal Antibody detects endogenous levels of BARD1 protein.

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    The antiserum was produced against synthesized peptide derived from human BARD1. AA range:1-50

  • Uniprot No

    Q99728

  • Alternative names

    BARD1; BRCA1-associated RING domain protein 1; BARD-1

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    BRCA1 associated RING domain 1(BARD1) Homo sapiens This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gen

  • Other

    BARD1, BRCA1-associated RING domain protein 1

  • Mol.Wt (Da)

    86648

  • Concentration

    1 mg/ml

Product Reactivity Applications Conjugation Catalog Images


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