Arkadia rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
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- 更新時間 2025/6/28 10:57:45
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Source
Rabbit
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Applications
WB,ELISA
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Reactivity
Human,Mouse
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Dilution
WB: 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
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Storage
-20°C/1 year
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Specificity
Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.
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Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950
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Uniprot No
Q6ZNA4
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Alternative names
RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
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Other
RNF111, E3 ubiquitin-protein ligase Arkadia
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Mol.Wt (Da)
108876
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Concentration
1 mg/ml
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