ATM mouse mAb(1D1)
- 公司名稱 上海貝博生物科技有限公司
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Source
Mouse
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Applications
IHC
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Reactivity
Human,Rat,Mouse
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Dilution
IHC 1:100-200
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Storage
-20°C/1 year
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Specificity
ATM protein detects endogenous levels of ATM
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Source/Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
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Immunogen
Recombinant Protein of ATM of ATM
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Uniprot No
Q13315
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Alternative names
ATM
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Monoclonal
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Isotype
IgG
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Background
ATM serine/threonine kinase(ATM) Homo sapiens The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],
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Other
ATM, ATM
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Concentration
1 mg/ml
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