S80036
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- 公司名稱 上海源葉生物科技有限公司
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- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2024/7/3 19:06:45
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生物試劑,ELISA試劑盒,對(duì)照品,標(biāo)準(zhǔn)品,培養(yǎng)基,透析袋,病理科耗材,實(shí)驗(yàn)室耗材
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- 產(chǎn)品描述： MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC50s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy
- 靶點(diǎn)： IC50: 1 nM (human SCD1), 3 nM (rat SCD1), 3 nM (mouse SCD1)
- 體內(nèi)研究： MK-8245 (10mg/kg; p.o.) exhibits a tissue distribution profile concentrated in the liver, with low exposure in tissues associated with potential adverse events in rats, dogs, and rhesus monkeys. MK-8245 improves glucose clearance in a dose-dependent manner in eDIO mice administrated before the glucose challenge
- 參考文獻(xiàn)：
1. Oballa RM, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.J Med Chem. 2011 Jul 28;54(14):5082-96. Epub 2011 Jun 28.
- 溶解度： Soluble in DMSO
- 保存條件： -20℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.14 ml 10.701 ml 21.401 ml 5 mM 0.428 ml 2.14 ml 4.28 ml 10 mM 0.214 ml 1.07 ml 2.14 ml 50 mM 0.043 ml 0.214 ml 0.428 ml
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