S80019
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- 公司名稱 上海源葉生物科技有限公司
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- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2024/7/3 18:48:59
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- 產(chǎn)品描述： Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH)
- 靶點(diǎn)： SIRT2:10 μM (IC50);SIRT1:21 μM (IC50);SIRT3:67 μM (IC50);HDAC8;MDM-2/p53
- 體內(nèi)研究： Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice
- 參考文獻(xiàn)：
1. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. 2. Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8]. J Biol Chem. 2020;jbc.RA119.012056. 3. Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622. 4. Yuan H, et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608. 5. Yuan H, et al. Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. Oncotarget. 2017 Feb 28;8(9):14912-14924.
- 溶解度： DMSO : ≥ 31 mg/mL (68.19 mM)
- 保存條件： 2-8℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.2 ml 10.998 ml 21.996 ml 5 mM 0.44 ml 2.2 ml 4.399 ml 10 mM 0.22 ml 1.1 ml 2.2 ml 50 mM 0.044 ml 0.22 ml 0.44 ml
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