犬瘟病毒IgG免疫熒光玻片

Canine Distemper IgG IFA Substrate slide

廣州健侖生物科技有限公司

主要用途：用于檢測狗血清中犬瘟病毒IgG抗體

產(chǎn)品規(guī)格：12 孔/張,10 張/盒

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犬瘟病毒IgG免疫熒光玻片

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-3室
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為了驗證他們的理論,，該研究組使用攜帶破傷風(fēng)毒素的病毒禁止星形膠質(zhì)細(xì)胞選擇性釋放化學(xué)物質(zhì)的能力,，有效地消除了細(xì)胞與鄰近細(xì)胞的溝通能力。神經(jīng)細(xì)胞不受毒素的影響,。
添加化學(xué)物質(zhì)引發(fā)動物大腦的伽馬波后,，研究人員發(fā)現(xiàn)，攜帶有缺陷的星形膠質(zhì)細(xì)胞的腦組織比含有健康細(xì)胞的組織產(chǎn)生更短的伽馬波,。而且,，添加三個允許研究人員有選擇地打開和關(guān)閉星形膠質(zhì)細(xì)胞的破傷風(fēng)毒素的基因后，他們發(fā)現(xiàn),，星形膠質(zhì)細(xì)胞的信號傳導(dǎo)被阻斷的小鼠的伽瑪波被削弱了,。關(guān)閉毒素則抗原抗體了這一效果。
星形膠質(zhì)細(xì)胞經(jīng)過修改后的小鼠看似*健康的,。但經(jīng)過幾個認(rèn)知測試后,，研究人員發(fā)現(xiàn)，它們?nèi)狈σ粋€主要領(lǐng)域：新物體識別,。正如預(yù)期的那樣,，健康小鼠比熟悉的物品花更多的時間在置放于其環(huán)境中的新物品。與此相反，該研究組的新突變小鼠處理所有的物品的時間都是相同的,。
“在某種意義上說,，這原來是個驚人的結(jié)果，新物體識別記憶不只是受損,，而是已經(jīng)沒了,，就好像我們刪除這一種形式的記憶，而其它完好無損,，” Sejnowski說,。
這個結(jié)果令人大吃一驚，部分原因是星形膠質(zhì)細(xì)胞在數(shù)秒鐘或更長的時間內(nèi)運(yùn)行,，而神經(jīng)元的信號卻遠(yuǎn)遠(yuǎn)比這個快多了,，它們是毫秒級別的。正因為如此慢的速度,，因此沒有人懷疑星形膠質(zhì)細(xì)胞參與了需要迅速做出決定的高速大腦活動,。
“傳統(tǒng)上認(rèn)為星形膠質(zhì)細(xì)胞只是神經(jīng)元和其他細(xì)胞的保護(hù)者和支持者，而現(xiàn)在發(fā)現(xiàn)它們也都參與了信息的處理和其他認(rèn)知行為,，我覺得這個觀點很*,，” 遺傳學(xué)實驗室和美國癌癥協(xié)會的維爾馬教授說。
這并不是說星形膠質(zhì)細(xì)胞變快了——它們?nèi)匀槐壬窠?jīng)元慢多了,。但新的證據(jù)表明,，星形膠質(zhì)細(xì)胞都在積極地為伽馬波發(fā)生提供合適的環(huán)境，這反過來又使大腦更容易學(xué)習(xí)和改變神經(jīng)元連接的強(qiáng)度,。

To validate their theory, the team used tetanus toxin-containing viruses to block the ability of astrocytes to selectively release chemicals, effectively eliminating the cells' ability to communicate with neighboring cells. Nerve cells are not affected by toxins.
After chemicals added to trigger the brain's gamma waves, the researchers found that brain tissue carrying defective astrocytes produced shorter gamma waves than tissues containing healthy cells. Moreover, after adding three genes that allow researchers to selectively open and close astrocytes in the tetanus toxins, they found that the gamma waves in mice blocked by astrocyte signaling were impaired It's Anti-toxin turned off this effect.
The modified astrocytes seem compley healthy. But after a few cognitive tests, the researchers found that they lacked one of the main areas: new object recognition. As expected, healthy mice spend more time placing new items in their environment than familiar items. In contrast, the new mutant mice in the study group treated all the items for the same amount of time.
"It turned out to be a surprising result in a sense that the new object recognition memory is not just damaged, but gone, just as if we deleted this form of memory while the rest were intact," Sejnowski said.
This result is astonishing, in part because astrocytes run in seconds or more, and neurons signal much faster than this, and are millisecond-scale. Because of this slow pace, no one suspects that astrocytes are involved in high-speed brain activity that requires quick decisions.
"Traditionally, astrocytes are considered the guardians and supporters of neurons and other cells and are now found to be involved in the processing of information and other cognitive behaviors, which I find very unique," said Genetics Room and Professor Wilmer of the American Cancer Society said.
This is not to say that astrocytes become faster - they are still much slower than neurons. But new evidence suggests that astrocytes are actively providing the right environment for gamma waves to occur, which in turn makes it easier for the brain to learn and change the strength of neuronal connections.